cellasys, Technische Universität München and MatTek In Vitro Life Science Laboratories present recent updates about our “Tissue-on-a-Chip” at the 22nd European Congress on Alternatives to Animal Testing:
In this study we demonstrate a microphysiometric system based on IMOLA‑IVD device that will allow real-time measurement of multiple parameters in human small intestine tissue model (EpiIntestinalTM). The parameters are measured non-invasively, while the system provides fresh nutrients and allows programmable repeated dosing of test articles. In the presented set of experiments we have concentrated on trans-epithelial electric resistance (TEER) as this parameter was previously established to reflect an integrity of EpiIntestinal tissue model. The performance of the system was verified and baselines were established by long term incubation of EpiIntestinal tissue in IMOLA-IVD, followed by single application of 2% SDS.